Portents of Death and Destruction - 15th Century.

XVIIth International Congress of Medicine: handbook of the Historical Medical Museum organized by Henry S. Wellcome (the Museum of the Section of the History of Medicine), London, 1913, catalogue no. 267, p. 62 (possibly this item, described as "Death, famine and pestilence as forecast by a comet. From a MS of the 15th century") - Wellcome

Beheading of Saint Catherine - c. 1480 - 1490

Giovanni da Modena, The Inferno (detail) - 1410, Basilica di San Petronio, Bologna. 

Hieronymus Bosch : Death and the Miser - c. 1485/1490.

Death and the Miser (also known at Death of the Usurer) is a Northern Renaissance painting by Hieronymus Bosch produced between 1490-1516 in Northern Europe. It is a memento mori painting, which is meant to remind the viewer of the inevitability of death and the futility of the pursuit of material wealth, illustrating the sin of greed.

The new Master of the Dresden Prayer Book (Flemish, active about 1480 - 1515) - The Temperate and the Intemperate, ca. 1475.

'The anonymous illuminator known as the Master of the Dresden Prayer Book was a painter of tremendous originality. Named after a book of hours now in Dresden, he worked in Bruges from around 1465 until about 1515. At a time when artists favored elaborate costumes and contrived postures, this illuminator gave his figures a sweeter, more innocent quality. He had an uncanny ability to locate the humor or irony in a familiar story, and he showed particular sympathy for coarse or simple characters. The novelty of his colors--including bright oranges, teals, burgundies, rich blues, and sometimes black--often arranged in surprising combinations, further attests to the refreshing originality of his art.'

Getty Center.

The Saint Elizabeth’s Day Flood, Master of the St Elizabeth Panels, Netherlands , c. 1490 - c. 1495 oil on panel, Rijksmuseum

Master of the Murano Gradual (Italian, active about 1430 - 1460) - Saint Jerome Extracting a Thorn from a Lion's Paw, Getty Center shop ready

Jonah and the Whale, Folio from a Jami al-Tavarikh (Compendium of Chronicles), Iran, ca. 1400 , Ink, opaque watercolour, gold, and silver on paper The Metropolitan Museum of Art, NYC.

Giovanni di Paolo : Saint Nicholas of Tolentino Saving a Shipwreck - 1457. Philadelphia Museum of Art.

Diagram for Sunday – detail , from Ms. Ludwig XII 8 , Anatomical-Physiological Description of Men; Liber Synonimorum; Descriptions of Planets, Zodiacs, and Comets; Treatises on Divination from Names, etc., German, shortly after 1464 – Unknown Illuminator 
Watercolour and ink on paper (Place Created) , ca, 1464 .Watercolor and ink on paper bound between original wood boards covered with original pigskin Getty Museum , LA Ms. Ludwig XII 8 (83.MO.137), fol. 53v Dimensions: Leaf: 30.6 × 22.1 cm (12 1/16 × 8 11/16 in.)